In the context of the aggravation of environmental problems, in particular those related to the use of forest resources, mineral and fuel and energy resources, the violation and degradation of natural ecosystems in large areas, it became necessary to preserve unique areas of the earth's surface. Monitoring of protected areas is an effective tool for maintaining unique natural complexes in a high-quality condition, reducing the level of degradation of the components of the natural environment. Currently, specially protected natural areas of the Tyumen region are experiencing high anthropogenic loads associated with industrial, tourist, and investment activities. To develop a methodology for monitoring the lands of unique natural complexes and objects of the Tyumen region, the main factors that have a negative impact on natural complexes are identified.