The research was conducted at Andropovsky Agrocomplex LLC in the Andropovsky Municipal District of Stavropol Krai from 2021 to 2023. The scientific novelty of the research was that for the first time in the Stavropol Krai, the effectiveness of the combined use of plant protection products was studied, along with the application of mineral fertilizers in winter wheat crops, at Andropovsky Agrocomplex LLC in the Andropovsky Municipal District. The experiment was two-factorial, consisting of the following factors. Factor A: mineral fertilizers. Factor B: plant protection system. The winter wheat variety Tanya was studied in the experiment. The experiment was a production experiment, repeated three times, with an area of ​​1.2 hectares each. Winter barley was the predecessor crop during the research period. The following fertilizers were used: 100 kg/ha (N10P26K26) of DAFK (diammophoska) for the main application, 100 kg/ha (N16P16K16) of NAFK (nitroammophoska) for sowing, 100 kg/ha (N35) of NaA (ammonium nitrate) as a top dressing during the tillering phase, and 100 kg/ha (N35) during the boot emergence phase. The maximum nitrate nitrogen content on average in the experiment was during the boot emergence phase of winter wheat (10.9 mg/kg), subsequently its decrease was observed, and the minimum values ​​were obtained at the phase of full crop maturity (8.2 mg/kg). On average, no reliable differences were observed between the studied plant protection systems in the experiment, and the difference between the system of Agro Expert Group LLC and the protection system was 0.69 mg/kg of soil. The maximum average mobile phosphorus content in the experiment was observed during the tillering phase of winter wheat (19.7 mg/kg), subsequently decreasing, and reaching its minimum values ​​at the full crop maturity stage (16.1 mg/kg). The studied fertilizer dose significantly increased the exchangeable potassium content compared to the control, with the difference amounting to 3-17 mg/kg during tillering, 6-22 mg/kg during the booting phase, 12-25 mg/kg during the heading phase, and 12-22 mg/kg at the full maturity stage.